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M94A2622.TXT
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1994-10-25
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Document 2622
DOCN M94A2622
TI HIV infection in children: mucocutaneous manifestations.
DT 9412
AU el Hachem M; Castelli G; Pianosi G; Krzysztofiak A; Livadiotti S; Ferri
M; Bambino Gesu Children Hospital, I.R.C.C.S., Rome, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):262 (abstract no. PB0479). Unique
Identifier : AIDSLINE ICA10/94369953
AB OBJECTIVE: Studies in adult suggest that mucocutaneous diseases are more
common in patients with HIV-1 infections or AIDS than in other persons.
The authors analyze differences in clinical course, severity and
persistence of mucocutaneous symptoms in children with HIV infection and
AIDS. RESULTS: The authors reviewed clinical records of 166 HIV-1
seropositive children, observed at Bambino Gesu children's Hospital in
Rome between 1990-1993. One hundred of them are infected (53 have AIDS),
and 66 were HIV positive at birth but not infected. For the whole length
of the study 46 (46%) infected patients showed one or more mucocutaneous
diseases with 114 clinical manifestations (mean 2.8/patient). Out of the
66 HIV seropositive but not infected children only 9 (14%) had
mucocutaneous diseases. Fungal infection (Candida) followed by viral
diseases such as Warts (8), Molluscum contagiosum (5) and Herpes (5) was
the most frequent diseases. DISCUSSION: In pediatric age the most
frequent mucocutaneous manifestations are infections, while the non
infective manifestations common in adults, as Kaposi and Sebhorroic
dermatitis, are exceptional in children. Also the common diseases, such
as Herpes simplex or fungal infection, often required laboratory
analysis or a mucocutaneous biopsy to be diagnosed because clinical
evidence are not typical. The majority of them are resistant to
conventional therapy. CONCLUSION: Mucocutaneous diseases are extremely
common in HIV-1 infected children. Their incidence increases as immune
function deteriorates. The clinical aspects of the skin disease is often
atypical with diagnostic difficulties and therapy resistance.
DE Acquired Immunodeficiency Syndrome/*DIAGNOSIS/EPIDEMIOLOGY AIDS-Related
Opportunistic Infections/*DIAGNOSIS/EPIDEMIOLOGY Child Child,
Preschool Cross-Sectional Studies Human HIV
Infections/*DIAGNOSIS/EPIDEMIOLOGY *HIV-1 Incidence Infant Infant,
Newborn Italy/EPIDEMIOLOGY Skin Diseases,
Infectious/*DIAGNOSIS/EPIDEMIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).